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In vitro anticancer activity of Zn-cobimetinib-levofloxacin-PVA/PVP nanofibers against A431 skin carcinoma cells after 24 h and 48 h of exposure, compared to untreated control (100% viability). Data are presented as mean ± SD ( n = 3 independent experiments). Statistical analysis was performed using one-way ANOVA followed by Tukey's post hoc test. p < 0.001 compared to control. The IC 50 values were calculated as 62 µg mL −1 (24 h) and 18 µg mL −1 (48 h).

Journal: RSC Advances

Article Title: Electrospun Zn-cobimetinib-levofloxacin-PVA/PVP nanofibers for skin-targeted anticancer and antimicrobial applications

doi: 10.1039/d6ra03437c

Figure Lengend Snippet: In vitro anticancer activity of Zn-cobimetinib-levofloxacin-PVA/PVP nanofibers against A431 skin carcinoma cells after 24 h and 48 h of exposure, compared to untreated control (100% viability). Data are presented as mean ± SD ( n = 3 independent experiments). Statistical analysis was performed using one-way ANOVA followed by Tukey's post hoc test. p < 0.001 compared to control. The IC 50 values were calculated as 62 µg mL −1 (24 h) and 18 µg mL −1 (48 h).

Article Snippet: All microbial strains utilized in the antimicrobial susceptibility tests, as well as all required materials for the anticancer assays, including A431 cancer cells and normal fibroblasts, were obtained from the American Type Culture Collection (ATCC).

Techniques: In Vitro, Activity Assay, Control

In vitro anticancer activity of free cobimetinib against A431 skin carcinoma cells after 48 h of exposure, compared to untreated control (100% viability). Data are presented as mean ± SD ( n = 3 independent experiments). Statistical analysis was performed using one-way ANOVA followed by Tukey's post hoc test. The IC 50 values were calculated as 24 µg mL −1 ( p < 0.002).

Journal: RSC Advances

Article Title: Electrospun Zn-cobimetinib-levofloxacin-PVA/PVP nanofibers for skin-targeted anticancer and antimicrobial applications

doi: 10.1039/d6ra03437c

Figure Lengend Snippet: In vitro anticancer activity of free cobimetinib against A431 skin carcinoma cells after 48 h of exposure, compared to untreated control (100% viability). Data are presented as mean ± SD ( n = 3 independent experiments). Statistical analysis was performed using one-way ANOVA followed by Tukey's post hoc test. The IC 50 values were calculated as 24 µg mL −1 ( p < 0.002).

Article Snippet: All microbial strains utilized in the antimicrobial susceptibility tests, as well as all required materials for the anticancer assays, including A431 cancer cells and normal fibroblasts, were obtained from the American Type Culture Collection (ATCC).

Techniques: In Vitro, Activity Assay, Control

Effect of O. basilicum var. basilicum (Obb) on A431 cells at different concentration.

Journal: Scientific Reports

Article Title: Phytochemical signatures and multifunctional bioactivities of two Ocimum basilicum varieties (Obb vs. Obg): antimicrobial, antioxidant, and anticancer potential

doi: 10.1038/s41598-026-53499-z

Figure Lengend Snippet: Effect of O. basilicum var. basilicum (Obb) on A431 cells at different concentration.

Article Snippet: The epidermoid carcinoma cell line A431 (ATCC CRL-1555) was obtained from the American Type Culture Collection.

Techniques: Concentration Assay

Effect of O. basilicum var. genovese (Obg) on A431 cells at different concentration.

Journal: Scientific Reports

Article Title: Phytochemical signatures and multifunctional bioactivities of two Ocimum basilicum varieties (Obb vs. Obg): antimicrobial, antioxidant, and anticancer potential

doi: 10.1038/s41598-026-53499-z

Figure Lengend Snippet: Effect of O. basilicum var. genovese (Obg) on A431 cells at different concentration.

Article Snippet: The epidermoid carcinoma cell line A431 (ATCC CRL-1555) was obtained from the American Type Culture Collection.

Techniques: Concentration Assay